mitochondrial toxicity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9491	Pyraclostrobin		Antibacterial , Antifungal
	Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.		Antibacterial , Antifungal
TN2436	4-methyl-6-phenyl-2H-pyranone	4-methyl-6-phenyl-2H-pyranone	Mitochondrial Metabolism
	4-methyl-6-phenyl-2H-pyranone is derived from Scutellaria baicalensis Georgi and improves mitochondrial functionality to protect astrocytes against hydrogen peroxide-induced toxicity.		Mitochondrial Metabolism
TWP2911	Thymidine	5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin	Others , DNA/RNA Synthesis , Endogenous Metabolite
	1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.		Others , DNA/RNA Synthesis , Endogenous Metabolite
T5481	TRi-1		Others
	TRi-1 is irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy		Others
T5S2129	Sciadopitysin		TNF , NF-κB
	Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in o...		TNF , NF-κB
T6S1930	Schisanhenol	Schizanhenol,Gomisin-K3	Antioxidant
	1. Schisanhenol (Schizanhenol) can protect against adriamycin induced heart mitochondrial toxicity. 2. Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals. 3. Schisanheno...		Antioxidant
T5692	Pyrroloquinoline quinone		Others , Endogenous Metabolite
	Pyrroloquinoline quinone (PQQ), as a well-known redox enzyme cofactor, PQQ can protect NS/PCs against glutamate toxicity associated with ROS-mediated mitochondrial pathway,		Others , Endogenous Metabolite
T60400	LDCA		Apoptosis , Dehydrogenase
	LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. ...		Apoptosis , Dehydrogenase
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
T3S1068	Oxyresveratrol	trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene	Tyrosinase , Autophagy , HSV
	1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxid...		Tyrosinase , Autophagy , HSV
T4364	Aftin-4	Aftin 4,Aftin4	Beta Amyloid , Gamma-secretase
	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus...		Beta Amyloid , Gamma-secretase
TN4883	Quinine sulfate dihydrate		Others
	Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassiu...		Others
T6S1653	Albiflorin	Alibiflorin	Reactive Oxygen Species
	1. Albiflorin (Alibiflorin) has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoniflorin significantly ameliorated Glu-induced ...		Reactive Oxygen Species
T5S1097	Neferine	(R)-1,2-Dimethoxyaporphine,(-)-Neferine	Apoptosis , NF-κB , Autophagy
	1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to a...		Apoptosis , NF-κB , Autophagy
T71241	Carbovir
	Carbovir, also known as (-)-Carbovir, is a nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) caused mitochondrial toxicity in human hepatoma carcinoma cell.
T62073	PI3Kα-IN-6
	PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor that exhibits anticancer effects without toxicity to normal cells. PI3Kα-IN-6 increases ROS production, decreases mitochondrial membrane potential and induces apoptosis.
T63864	Antiproliferative agent-4
	Antiproliferative agent-4 showed good anti-proliferative effects on some cancer cells. antiproliferative agent-4 inhibited tumour growth in nude mice and showed low toxicity. antiproliferative agent-4 reduced the mitocho...
T73600	Cefaloglycin
	Cefaloglycin (Cephaloglycin), an orally active, nephrotoxic β-lactam cephalosporin antibiotic, exhibits antibacterial activity primarily against Gram-Positive cocci, excluding enterococci. It impairs mitochondrial substr...
T73125	SMTIN-T140		HSP
	SMTIN-T140 (compound 6a), a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor with an IC50 of 1.646 μM, exhibits anticancer activity by inducing mitochondrial dysfunction, elevating mitochondri...		HSP
T70431	TX-1123
	TX-1123 is a potent inhibitor of protein tyrosine kinase (PTK), specifically targeting Src, eEF2-K, PKA, and EGFR-K/PKC. Additionally, it acts as a cyclo-oxygenase (COX) inhibitor, displaying IC50 values of 1.16 μM for C...